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Calling GWAS Longevity Calls into Question

According to Nature's The Great Beyond blog, the GWAS published in Science last week that identified SNPs for "exceptional longevity" has generated some criticisms within the community. Critics are calling the findings of Paola Sebastiani et al. into question amid inquiries of "subtle biases" and the team's use of "different versions of the SNP chips" from Illumina, according to Nature. The Wellcome Trust Sanger Institute's Jeffery Barrett told the Guardian that "some of the genetic variants in this study are claimed to have much, much stronger effects on longevity than we've seen in similar studies of diabetes, heart disease, and cancer. For instance, the strongest single effect makes someone 10 times more likely than average to be extremely long-lived, compared to other complex diseases where typical variants only make someone, say, one and a half times as likely to be diabetic," highlighting his skepticism. According to Nature, Sebastiani says that the variants they've reported have larger effects since becoming a centenarian is a much rarer condition than having diabetes.

Last week, the New York Times' Nicholas Wade reported that DeCode Genetics' Kari Stefansson, who has run a similar experiment using a larger group of centenarians, did not find any of Sebastiani et al.'s 150 variants in his cohort.

Nature reports that Sebastiani and her team are considering "holding an online chat next Wednesday to answer questions" and to quell any confusions that their work has generated.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.