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Building Math Expertise

Biology is increasingly a numbers game, and newly trained biologists need to have good math skills. Scientific Blogging reports that the UK's Biotechnology and Biological Sciences Research Council is calling for researchers to submit examples of how they use mathematics in their work so that they can be used in the classroom to show studies how math is applied in modern biology research. "We want to work with researchers to develop fun, engaging examples of the actual maths in use at the cutting edge of bioscience," says BBSRC's Tristan Bunn in a statement, "so that budding young scientists are aware from an early stage of how interlinked the two subjects are and to embrace this, not be daunted by it."

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.