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BRCA1 Doesn't Act Alone

A paper in PNAS this week looks at how mutations in genes associated with breast cancer affect BRCA1, a tumor suppressor gene that when mutated leads to breast, ovarian, and prostate cancers. Analyzing data from NCI's CGEMS project on 18 breast cancer-related genes, statisticians from Columbia and Harvard found that there are "many interesting interactions" between BRCA1 and other genes, suggesting that mutations in these genes maybe predispose people to cancer even if they don't carry usual BRCA1 mutations known to cause cancer.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.