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Biomarkers for Prostate Cancer

The University of Michigan's Arul Chinnaiyan has led a study that identified several biomarkers for advanced stage prostate cancer, says an article at BBC. The researchers examined 1,126 molecules in a total of 262 samples of tissue, blood, or urine, and found one metabolite, sarcosine, to be a better predictor of late-stage disease than PSA. While a simple urine test is still around five years away, they say, it's promising work. "It raises the possibility of telling the difference between the type of cancer that does no harm -- which we term 'the pussycat' -- from the type that does -- which we call 'the tiger,'" says Malcolm Mason, a cancer expert at the University of Cardiff. "If we are able to distinguish the tiger from the pussycat it could make a real difference."

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.