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Biological Surprises = Drug Discovery Job Security

In the Pipeline's Derek Lowe reminds us once again of the universe of protein/insert-your-favorite-but-less-studied-ligand-here interactions that we have yet to embrace when it comes to small molecule drug discovery research. Here, he blogs about a new paper published in PNAS, whose authors have reported the X-ray crystal structure of the first identified outer mitochondrial membrane iron-sulfur protein. The protein, called mitoNEET, contains a unique fold and was also found to bind pioglitazone, a protein used to treat type 2 diabetes. Considering the doors of possibilities it could open into drug research, Lowe writes, "Ah, we'll all be employed forever in this business, for as long as people can stand it."

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.