In the Pipeline's Derek Lowe reminds us once again of the universe of protein/insert-your-favorite-but-less-studied-ligand-here interactions that we have yet to embrace when it comes to small molecule drug discovery research. Here, he blogs about a new paper published in PNAS, whose authors have reported the X-ray crystal structure of the first identified outer mitochondrial membrane iron-sulfur protein. The protein, called mitoNEET, contains a unique fold and was also found to bind pioglitazone, a protein used to treat type 2 diabetes. Considering the doors of possibilities it could open into drug research, Lowe writes, "Ah, we'll all be employed forever in this business, for as long as people can stand it."