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Binding Sites, Moving Targets

Sep 10, 2008

University of Pennsylvania scientists have applied the Derived Allele Frequency distribution test of neutrality on a set of transcription factor binding sites to find that many human- and primate-specific sites are likely evolving under positive selection. They published their findings today in PLoS ONE, showing that genes whose TF binding sites contain "high frequency derived alleles are enriched for positive regulation of protein metabolism and developmental processes," they write.

Breaking News
The Scan

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