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Binding Data For Everyone

The NIH will invest $5 million over five years to fund a new open-access database for molecular binding data, called the Community Structure-Activity Resource, says a post at Open Access News. Led by the University of Michigan, the Web-based resource will gather data from existing sources, like Binding MOAD and PDBbind, and work with pharma companies to create new data for enhanced computational modeling of predicted drug targets. In a similar project based on the wiki format, WikiProteins hopes to lure researchers to start annotating proteins for binding properties and function.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.