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Big Blue and the Genome

IBM is getting in on the $1,000 genome race — and plan to bring that cost even lower, to $100. The company's approach is based on what it calls "DNA transistor," reports the New York Times. (Our sister publication GenomeWeb Daily News covers this here.) IBM plans to develop a silicon-based system containing a million nanopores through which DNA can be ratcheted to sequence a genome in a few hours. "To bring about an era of personalized medicine, it isn't enough to know the DNA of an average person," says IBM's Gustavo Stolovitzky. "As a community, it became clear we need to make efforts to sequence in a way that is fast and cheap." However, Elaine Mardis tells the Times that previous attempts to develop a silicon-based nanopore system didn't pan out. "DNA strands seem to have a mind of their own," she says.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.