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Better Ways to Get the Right Dose

Keith Robison at Omics! Omics! points out a paper in PNAS in which Regeneron shows that a compound it developed called VEGF-Trap can be used to measure the amount of circulating VEGF (vascular endothelial growth factor) in blood. VEGF is a signaling molecule that stimulates angiogenesis, and is therefore used to determine dosage for drugs used to treat cancer. By measuring the amount of free and VEGF-complexed VEGF-Trap, they found that they can measure levels of VEGF and identify a dose which ensures that the most trapping occurs.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.