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A Better Understanding of Clubfoot

Researchers at the Washington University School of Medicine are closer to understanding the birth defect that unites Damon Wayans, Dudley Moore, Kristi Yamaguchi, Troy Aikman, and Lord Byron: clubfoot. The findings, based on a genome-wide analysis that will appear in next week's American Journal of Human Genetics, show that clubfoot is likely to be caused by mutations in the PITX1 gene, which is thought to be involved in early lower limb development. "Identifying the genes for clubfoot will allow for improved genetic counselling and may potentially lead to new and improved treatment and preventive strategies for this disorder," lead author Matthew Dobbs told CBC News. He hopes that the research will one day make painful physical therapy treatments a thing of the past.

 

The Scan

Vaccine Update Recommended

A US Food and Drug Administration panel recommends booster vaccines be updated to target Omicron, CNBC reports.

US to Make More Vaccines for Monkeypox Available

The US is to make nearly 300,000 vaccine doses available in the coming weeks to stem the spread of human monkeypox virus, according to NPR.

Sentence Appealed

The Associated Press reports that Swedish prosecutors are appealing the sentence given to a surgeon once lauded for transplanting synthetic tracheas but then convicted of causing bodily harm.

Genome Biology Papers on COVID-19 Effector Genes, Virtual ChIP-seq, scDART

In Genome Biology this week: proposed COVID-19 effector genes, method to predict transcription factor binding patterns, and more.