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A Better Look at Synesthesia

A new study in the American Journal of Human Genetics has performed the first whole-genome linkage scan for synesthesia, which is known to run in families and to affect women more than it does men. Researchers found four candidate regions on chromosomes 2q24, 5q33, 6p12, and 12p12, and revealed that the disease, in which sounds are perceived as colors, is not X-linked as was previously thought. "The genetics of this form of synesthesia -- and probably that of other forms -- is far more complex than previously thought," says Mo at Neurophilosophy. Also of note, he points out the region with the strongest linkage is located on chromosome 2, known to contain a gene associated with autism. "Like synesthesia, autism involves sensory and perceptual abnormalities, and autistics often report synesthesia-like symptoms," he adds.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.