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Better Knowledge, Better Treatments

Better understanding the mutations that a tumor has not only increases researchers' knowledge of cancer, it also improves treatments for cancer patients, MIT's Phillip Sharp tells The Boston Globe. Sharp is part of the Stand Up to Cancer organization that funds "dream teams" of researchers, including one that is investigating how some cancer cell genes are turned off by DNA modifications. "[One dream team has] found ways to reverse those modifications, and it appears to make tumors sensitive to drugs they have become resistant to," Sharp says. "If that pans out in bigger studies which are ongoing, it's quite exciting in terms of patients."

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.