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Behind the Scenes

At the US Centers for Disease Control and Prevention's Genomics and Health Impact blog this week, Muin Khoury — who directs the agency's Office of Public Health Genomics — describes "a day in the invisible life of public health genomics." Khoury narrates a hypothetical workday for a fictitious woman, who, like most of the public, he says, does not "realize that public health is at work to help make sure that genomic technologies are used to benefit all people." For example, when the woman wakes up to hear the newscaster announce the day's forecasted air quality, she may not realize that beyond monitoring how pollutants affect one's physiology, "public health researchers are also studying how such levels are affected by genetic factors and are developing programs to cut down on pollutants based on such knowledge," Khoury says.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.