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Bad Day for Ethanol Precipitation

Nick Oswald at Bitesize Bio considers a study of various approaches to desalting DNA for electroporation and concludes that "for the high concentration samples the microcolumns were the clear winner, although dialysis and gel filtration gave just a 2-fold lower efficiency." He adds that microcolumns were also best for low concentration samples -- and in this case were "at least 100x more efficient than any of the other methods." On a side note, he says, "For some reason, ethanol precipitation, a widely used method of desalting DNA, gave miserable results for both samples."

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.