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Bad Day for Ethanol Precipitation

Nick Oswald at Bitesize Bio considers a study of various approaches to desalting DNA for electroporation and concludes that "for the high concentration samples the microcolumns were the clear winner, although dialysis and gel filtration gave just a 2-fold lower efficiency." He adds that microcolumns were also best for low concentration samples -- and in this case were "at least 100x more efficient than any of the other methods." On a side note, he says, "For some reason, ethanol precipitation, a widely used method of desalting DNA, gave miserable results for both samples."

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.