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Back to the Drawing Board for Fixing the O-Line

Daniel MacArthur at Genetic Future reacts to 23andMe's news about a genome-wide association study seeking to identify variants connected to athletic prowess. The study, which compared 100 NFL players to a set of controls, failed to locate genetic differences that might explain the football players' athletic skill.

MacArthur calls the results "unsurprising," noting that the study was underpowered for finding variants of modest effect. "A genome-wide association study on a highly complex trait with a sample size of 100 has, historically speaking, a vanishingly small chance of yielding any positive results at all," he writes. "If you want to do a GWAS for athletic performance, at least wait until you have a homogeneous sample that's well-powered enough to have a fighting chance of detecting real associations."

The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge is weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.