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Arthur Horwich Wins the Lasker Award

Yale University's Arthur Horwich and Max Planck Institute of Biochemistry's Franz-Ulrich Hartl have won this year's Albert Lasker Basic Medical Research Award. In The New York Times this week, Carl Zimmer profiles Horwich, whose work Zimmer describes as spanning the worlds of both basic science and medicine. Horwich, who often collaborates with Hartl, discovered that cells contain "microscopic boxes, known as HSP60," Zimmer says, adding that those boxes are like "a changing room for proteins. Once they enter the box, proteins can fold themselves into their final shape so they can begin to do their jobs." Meanwhile, misfolded proteins have been implicated in a host of diseases, including Alzheimer's, and Horwich is working on determining whether cells can be induced to produce more HSP60 to help with protein folding and thus possibly treat disease. "The hope is that we'll get better and better at providing something for people who get sick," Horwich adds.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.