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Are Fruit Flies Man Enough?

Researchers at Brown University have found that male fruit flies can express a protein that lets them upregulate their X chromosome in order to compensate for "genetic shortcomings," reports LiveScience's Jennifer Welsh. In order for male Drosophila to survive, the researchers write in their study published in Nature, they have to regulate the imbalance created by having only one X chromosome, and they do it by expressing the male-specific lethal protein which doubles the gene expression on the X chromosome, Welsh says. "The finding, if it holds up in humans, could help scientists understand the basis of some X chromosome-linked diseases, which are much more frequent in men because they only have one copy of each X chromosome gene," she adds.

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.