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Are You Up With All the Big Papers of the Year?

Dec 18, 2009

The Scientist has come up with a list of the top five hottest papers of 2009. Drawing on information from ScienceWatch and ISI, it reports that the top two topics of the year were stem cells and, no surprise to us here, genomics. The second-to-top paper is the Frazer et al Nature paper on the latest HapMap. And coming in first is the Yamanaka group's work on inducing pluripotent stem cells.

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Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.