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Are Those Genes For Real?

In DNA sequencing, many genes are actually predicted by algorithms but never functionally confirmed. Results from two studies "suggest there's a considerable rate of error creeping into experiments that rely on the gene sequences that are predicted by current algorithms," says a post at Ars Technica. In one published in August in BMC Bioinformatics scientists used a software called MisPred, which scanned protein domains to find unlikely matchups and therefore questionable genes. In another study in PLoS, researchers isolated all the proteins from Arabidopsis cells and mapped the fragments back to the genome. They found that more than 18,000 were from sequences outside known genes, and they identified nearly 800 new genes and corrected for errors in another 700 predicted genes.

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.