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Applying Chemistry to Pecans

The title of Derek Lowe's blog post is "Applied Organic Synthesis: Chocolate Pecan Pie" and to us that sounded like a great way to put chemistry to use. Just follow his protocol to get some tasty pecan pie. He's helpfully converted the measurements into the metric system for non-US readers, but you can also pretend you're still at the bench. "Note that this product has an extremely high energy density — it's not shock-sensitive or anything, but make the slices fairly small," Lowe adds.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.