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And Now the 2500

Illumina announced the introduction of its HiSeq 2500 and upgrades to its MiSeq platform yesterday, according to a company press release. The HiSeq 2500 is expected to be able to sequence a genome in about a day, and, as our sister publication In Sequence reports, it is priced at $740,000 or $50,000 for an upgrade from the HiSeq 2000. In addition, the MiSeq will have increased throughput, longer reads, and a faster run time, Illumina says.

Illumina's announcement came the same day as one from Life Technologies, setting up a sequencing "battle," as Matthew Herper at Forbes puts it. The difference between the machines, he adds, will be data quality and cost.

"The speed is good, but the cost is going to be a blocker," for the Illumina machine, the Broad Institute's Chad Nusbaum tells Herper.

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.