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And It All Comes Together

Nov 13, 2007

Japanese researchers performed quantitative trait loci analysis on more than 1,000 mice to look for the mechanism behind prepulse inhibition, which is decreased in schizophrenia. Of the candidate genes, FABP7-deficient mice had a decreased prepulse inhibition, a shorter startle response latency, and had a greater effect on male mice. The researchers report in PLoS Biology that the FABP7 gene links three theories of schizophrenia pathology: the NMDA, neurodevelopmental, and glial theories.

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