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Analyzing Synthesis

Feb 25, 2010

The University of Southern California’s Oscar Aparicio and his colleagues describe how they conduct a genome-wide analysis of DNA synthesis in this month’s CSHL Protocols. In their approach, they couple BrdU immunoprecipitation with DNA microarrays to find BrdU-labeled chromosomal DNA throughout the genome. “BrdU-IP-chip has many potential applications and has already been used to identify replication origins, make quantitative comparisons of origin firing between strains, and examine replication fork progression,” the authors write.

HT: Bench Mark’s David Crotty

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