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The Amazing Giardiasis Dreamcoat

Some 280 million cases of giardiasis occur in the world each year and its infectivity is due to its "genomic wardrobe," according to this New York Times story. Biologists led by Hugo Luján at the Catholic University of Córdoba in Argentina have discovered that the parasite uses RNAi to silence expression of all but one of its 190 coat proteins to confer resistance to immunity. By blocking expression of the RNA-dependent RNA polymerase and Dicer, researchers created a bug that expressed all 190 coat proteins. While it might not be able to be used to make a vaccine for giardiasis, it "may be conceptually applicable to malaria," says Kirk Deitsch at Weill Cornell Medical College.

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.