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All the Ps

In MIT's Technology Review, Lee Hood discusses his P4 — "powerfully predictive, personalized, preventative — meaning we'll shift the focus to wellness — and participatory" — medicine idea. When asked what technologies will spur this change, Hood says that patient genomes will be "a standard of medical records in 10 years or so," that protein levels in blood will be measured using nanotechnology approaches, and that single cell analysis will aid in understanding disease states. The challenges, he says, are the data and societal acceptance. Hood adds that he is starting a P4 Medical Institute. "The idea is to bring in industrial partners as part of this consortium to help us transfer P4 medicine to the patient population at Ohio State University, which is both the payer and provider for its employees," he says.

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.