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All the Network's Pieces

An article in this week's issue of Cell describes a new computational model, called NetworKIN, that can determine what kinase works at a phosphorylation site and that improves the accuracy with which signaling networks can be constructed. Researchers led by Rune Linding applied their approach of combining amino acid sequence analysis with text mining of signaling pathway and protein interaction databases to DNA damage signaling. They determined that 53BP1 is phosphorylated by CDK1 and Rad50 by ATM and predict that BCLAF1 is a GSK-3 substrate.

The Scan

Rise of BA.5

The New York Times reports that the Omicron subvariant BA.5 has become the dominant version of SARS-CoV-2 in the US.

UK Health Secretary Resigns

Sajid Javid, the UK health secretary, resigned along with Chancellor Rishi Sunak, saying they cannot work with Prime Minister Boris Johnson's government, CNN reports.

Clones From Freeze-Dried Cells

A team in Japan has cloned mice from freeze-dried skin cells, according to the Guardian.

Genome Research Papers on Craniosynostosis, Macaque Retrotransposition, More

In Genome Research this week: structural variants in craniosynostosis, LINE-1 activity in rhesus macaque brain, and more.