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All the Network's Pieces

An article in this week's issue of Cell describes a new computational model, called NetworKIN, that can determine what kinase works at a phosphorylation site and that improves the accuracy with which signaling networks can be constructed. Researchers led by Rune Linding applied their approach of combining amino acid sequence analysis with text mining of signaling pathway and protein interaction databases to DNA damage signaling. They determined that 53BP1 is phosphorylated by CDK1 and Rad50 by ATM and predict that BCLAF1 is a GSK-3 substrate.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.