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All the Genomes

One problem with personal genomics, writes John Rennie at Smart Plant's Savvy Scientist, is that people don't have just one genome. Rather, Rennie says, people can be mosaics with various inactivated chromosomes; mothers may be chimeras, containing their fetus' DNA; and neurons, for example, appear to have rearrangements that other tissues do not. Never mind the microbiome, he adds. "The full biomedical significance of mosaicism and chimerism won’t be known for a long time," Rennie writes, later adding: "Genome sequencing costs better keep falling. We’re going to need a lot of it."

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.