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All the Genomes

One problem with personal genomics, writes John Rennie at Smart Plant's Savvy Scientist, is that people don't have just one genome. Rather, Rennie says, people can be mosaics with various inactivated chromosomes; mothers may be chimeras, containing their fetus' DNA; and neurons, for example, appear to have rearrangements that other tissues do not. Never mind the microbiome, he adds. "The full biomedical significance of mosaicism and chimerism won’t be known for a long time," Rennie writes, later adding: "Genome sequencing costs better keep falling. We’re going to need a lot of it."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.