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US Senator Tom Coburn (R-OK) released a report last week that discusses what it calls mismanagement at the National Science Foundation. "This includes tens of millions of dollars spent on questionable studies, excessive amounts of expired funds that have not been returned to the Treasury, inadequate contracting practices that unnecessarily increase costs, and a lack of metrics to demonstrate results," Coburn writes in an introductory letter to the report.

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A small, early-stage trial of a combination therapy for brain cancer reports favorable responses in two patients, according to the Guardian.

Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

In PLOS this week: sex-stratified genome-wide association study of chronic pain, sequencing data from Indigenous Mexican groups, and more.