After the Test

Actress and director Angelina Jolie writes in the New York Times that she decided to undergo a preventive double mastectomy after learning that she carries a mutation in her BRCA1 gene. Jolie's doctors estimated that she had an 87 percent risk of developing breast cancer and a 50 percent risk of ovarian cancer. Jolie's mother, Marcheline Bertrand, died of ovarian cancer at 56.

After her surgery, Jolie says she now has a less than 5 percent chance of developing breast cancer.

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In PNAS this week: human T cell editing with CRISPR, retrotransposons acting as insulators, and more.

The New York Times' George Johnson muses on cancer's roots in multicellularity.

The San Diego Union Tribune wonders whether Medicare is ready for personalized medicine.

Jun Wang, the chief executive of BGI, has stepped down.