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After the Sequence

At the Loom, Carl Zimmer bemoans what he dubs the "Yet-Another-Genome Syndrome." Sequencing a genome, he writes, used to be different — it took forever to do and was a big deal when it came out — but with next-generation sequencing, it takes comparatively no time at all, yet they still generate tons of press releases and news articles. It's what comes after the sequencing, Zimmer says, that is interesting. "What remains truly exciting is the kind of research starts after the genomes are sequenced: discovering what genes do, mapping out the networks in which genes cooperate, and reconstructing the deep history of life," he writes, adding that "insights like these are newsworthy. The sequencing of those genomes, on its own, is not."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.