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Advantage? Maybe, Maybe Not

In a new Genome Research paper, Pavel Pevzner asks whether read length matters. He and his colleagues use a new tool called EULER-USR to assemble mate-paired short reads. They saw that when the read length exceeds a threshold -- about 35 nucleotides in E. coli -- the efficiency of turning mate-pairs into mate-reads is 100 percent, and the read length does not matter, though they add that larger genomes have higher thresholds. Thus, the researchers say it is uncertain if long reads have an advantage over short reads.

 

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.