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While the human reference genome is done, it's not quite complete. There are a number of regions of the genome that researchers have had trouble accessing, especially near heterochromatic regions and sequences containing a number of repeats. Researchers led by the Broad Institute's Steven McCarroll turned to using an admixture mapping approach to open up those regions, as they describe in this week's American Journal of Human Genetics.

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In PLOS this week: computational strategy for improving gene set analysis testing, miRNAs linked to sleep apnea, and more.