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Technology Spotlight: Washington University

Following are select notable biotechnologies available for licensing from Washington University (source: Washington University Office of Technology Management):
Tech: Image-guided electrophysiologically determined treatment of atrial fibrillation
IP Status: Applied for patent (US patent application No. 20070049816)
Lead Inventor: Ralph Damiano
Description: Surgical method to treat atrial fibrillation, a condition affecting 2 million Americans. The method uses a patient’s own geometry and electrophysiology to “dramatically” improve surgery success rates.

Tech: Diagnostic method for sepsis
IP Status: US patents issued (US patent No. 6,939,716)
Lead Inventor: Jay Heinecke
Description: Sepsis test analyzes 3-chloro/bromotyrosine biomarkers to diagnose and measure treatment efficacy for the leading cause of death in the elderly and critically ill – 1,400 patients each day, according to Washington University.

Tech: Load-independent index of diastolic function
IP Status: Applied for patent (not yet published)
Lead Inventor: Sandor Kovacs
Description: Load-independent index of diastolic function enables direct, non-invasive measurement of heart’s actual functionality as a pump, as opposed to only volume of blood pumped.

Tech: SXC air filtration system
IP Status: US patent issued (US patent No. 6,861,036)
Lead Inventor: Pratim Biswas
Description: Air filtration system captures bio-particles as small as 5 nm with maximum efficiency and uses specialized titanium dioxide to destroy harmful microbes in the air. The technology could be useful for lab hood filtration systems.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.