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Empire State Development Corp., Greater Owensboro Economic Development Corporation, Illinois Science + Technology Park, Emergent Technologies, Quintiles, WP Carey Group, Pennsylvania Industrial Development Authority, Pennsylvania Department of Community a

Johnson & Johnson Unit Commits to $80M Expansion in Rochester, NY
Ortho-Clinical Diagnostics, a Johnson & Johnson unit that provides diagnostic solutions, will undertake an $80 million expansion of its research headquarters in Rochester, NY.
Ortho, which is headquartered in Raritan, NJ, has promised to retain its existing workforce of more than 1,100 people, and add 50 new jobs over the next three years. In return, Ortho has been awarded a $2 million capital grant from the state’s economic development agency, Empire State Development Corp.

“We estimate that without this project, 590 jobs would have been at risk” of leaving the state, said Daniel Gundersen, upstate chairman of Empire State Development, in a Jan. 10 press release.

In addition to purchasing machinery and equipment, Ortho-Clinical will acquire Building 313 at Kodak Park, a building it now leases. Ortho-Clinical employs more than a combined 1,100 people at both Kodak Park in Rochester, where it maintains its research HQ, and near the city in the suburban town of Greece.

Owensboro, Ky., Attracts Second Life Sciences Company from California
Biotherapeutics developer Intrucept Biomedicine has agreed to relocate its operations from Vacaville, Calif., to the Kentucky BioProcessing facility within MidAmerica Airpark in Owensboro, Ky., the Greater Owensboro Economic Development Corporation announced last week.
Intrucept is the second California-based plant pharmaceutical company to move across the country to Owensboro in the past six months. In October, San Diego-based Mapp Biopharmaceutical relocated part of its operation to the KBP campus. The campus consists of a 30,000-square-foot biomanufacturing plant and a 22,000-square-foot greenhouse complex.
Intrucept is headed by two former executives of Large Scale Biology Corp. Large Scale completed the campus in 1998, and sold it to KBP in 2006, a year after filing for bankruptcy protection. KBP is a subsidiary of Owensboro Medical Health System.
Intrucept is the first Owensboro-based company to qualify for state funding through Emerging Ventures, the new Owensboro office of the Central Region Innovation and Commercialization Center. The funds will qualify them for the new Emerging Ventures Fund, created by the Owensboro City Commission as a seed capital fund to entice technology-based companies like Intrucept to locate in Owensboro.
EDC President Nick Brake said in a press release that KBP is among anchors of an emerging plant-based biomanufacturing cluster anchored by the Owensboro Cancer Research Program and its partnership with the University of Louisville, and the surrounding agricultural community.
In 2006, Intrucept Biomedicine obtained a commercial license from the National Institutes of Health to a plant-derived, broad-spectrum antiviral protein that can be produced at KBP.

Illinois Science + Technology Park Sees Expansion by Healthcare Provider
Evanston Northwestern Healthcare, a Chicago health care provider, will expand its offices and conference/meeting areas to its existing space at the Illinois Science + Technology Park in Skokie, Ill., owned by Forest City Science + Technology Group.
ENH will be adding approximately 24,218 square feet on two floors of 4901 Searle Parkway, bringing its occupancy to more than 154,000 square feet — the largest institutional tenant at the campus. 4901 Searle Parkway is one of four buildings within the 23-acre, 660,000-square-foot campus, which was formerly a Pfizer facility.
ENH moved to Illinois Science + Technology Park in 2006 and now houses there its office operations, call center, training and data center functions. ENH operates three hospitals, a namesake medical group with 65 offices and facilities, a home care provider, a research institute, and the ENH Foundation. 
Forest City Science + Technology group is a division of Cleveland-based Forest City Enterprises. The $10 billion, publicly traded developer operates more than 2 million square feet of life science/technology office space, and has more than 8 million square feet in planning or development stages.

Expansion Nearly Complete, Cold Spring Harbor Labs Wins $2M for New Equipment
Cold Spring Harbor Laboratory is close to completing its $200 million, 100,000-square-foot Hillside Research Campus, Gov. Eliot Spitzer and CSHL President Bruce Stillman said last week, in a statement issued following a Jan. 11 visit by the governor to the 110-acre laboratory property.
During the visit, Spitzer announced a $2 million economic development grant from the state’s Empire State Development Corp. toward the $13 million cost of equipment for the six-building Hillside campus. The equipment purchase is tied to a promise by CSHL to create 80 new jobs over the next three years. The laboratory, which now employs 800 people, projects that each new job will spawn five additional support jobs.
The grant is CSHL’s second in five years for Hillside. In 2003 under Spitzer’s predecessor, George Pataki, the state awarded a $20 million grant toward the new campus. “Several” unnamed philanthropists have joined the state in investing in the project, Spitzer said in the announcement.

Long Island has been an anchor of the state’s life science effort, though its future is being challenged by its inability to keep educated young adults from moving out of the region due to its sky-high housing costs and other expenses [BioRegion News, July 2].


Life Sciences VC Firm Doubles its Austin, Tex., Operations, Adds New Lab Space
Emergent Technologies, a venture capital firm focused on financing life science companies, has relocated its corporate headquarters within Austin, Tex., to a three-story, 23,000-square-foot building at 11412 Bee Caves Road. The building’s first floor consists of wet-lab space to be occupied by four of ETI's 14 life sciences portfolio companies; the second and third floors, executive offices.

Since fall 2006, ETI has closed its $27 million University of Texas System Fund IV, spun three start-up companies out of the UT system, and more than doubled its personnel.

The ETI state-of-the-art building more than doubles the space of the firm's previous facilities, at 2508 Ashley Worth Blvd., and now will incorporate research laboratory operations and management offices in one location.


Quintiles Opens New Consolidated Lab Facility in Beijing
Quintiles Transnational has expanded and consolidated its Global Central Laboratories and Clinical Development Services units in Beijing to accommodate its growing business in China.
The new consolidated Quintiles China facility, with more than 17,000 square feet of space, is located at Sun Dong Ann Plaza in Beijing, about one block from the previous lab site in the Peking Union Medical College Hospital. The new facility expands the lab space by 2,600 square feet. The lab has 13 employees and continues to add staff.
CDS occupies 10,000 square feet of the combined office area, a major expansion over its old facility of under 3,000 square feet. The CDS staff strength continues to grow in Beijing and is expected to reach more than 60 people over the next 12 months.
Quintiles Transnational employs more than 19,000 people and maintains offices in more than 50 countries

WP Carey Acquires PerkinElmer Industrial/Office Research Facility in Finland
CPA(R):14, a publicly held non-traded REIT affiliate of investment firm WP Carey and Company LLC, has acquired an industrial/office research facility in Turku, Finland, for approximately $14.5 million.
The facility is being leased to Wallac Oy, a subsidiary of PerkinElmer, under a long-term lease. The acquisition follows an approximately $25 million sale-leaseback of an adjacent research and production facility that CPA(R):14 completed with PerkinElmer in 2001. Both properties are located in Turku's “Bio Valley,” a section of the city named for its concentration of science, business and biotech-related services.
The Turku facility serves as the headquarters for PerkinElmer's genetic screening business worldwide, though a significant portion of the facility is also used for research and development.

Pennsylvania Agencies Commit Almost $1M to Three Life Sciences Companies
Two Pennsylvania agencies have committed just under $1 million in subsidies to three life science companies planning expansion of the facilities and workforces statewide:
Welch Phoenixville — the owner of biotechnology companies Mitos Technologies, Mito Molding and Mitos BioSystems — has been approved for a $642,177 loan from the Pennsylvania Industrial Development Authority toward improvements for a new facility in Upper Providence Township, Pa. The companies will occupy half of a 40,000-square-foot building now under construction.
In return for the subsidy, Welch Phoenixville has promised to retain all 24 existing employees, transfer them to the new site, as well as create 47 new jobs. The $2.1 million project was shepherded through PIDA by the Montgomery County Industrial Development Corporation.
Auxilium Pharmaceuticals has been approved for $255,000 from the Pennsylvania Department of Community and Economic Development, toward a $7 million expansion of its Horsham, Pa., operations. Auxilium is upgrading its 50,000-square-foot biologics development facility, purchasing and installing equipment, and making leasehold improvements. The company will receive a $60,000 opportunity grant, $75,000 in customized job training funds and $120,000 in job creation tax credits.
Auxilium has agreed in return to create at least 60 jobs within three years and retain 27 existing positions by expanding. The specialty biopharmaceutical company will also retain 90 employees at its Malvern, Pa., headquarters. Auxilium teamed up with the Montgomery County Industrial Development Corporation to pursue the funds.
Invivodata, a developer of softwaresolutions focused on electronic patient reporter outcomes for global clinical research, has been approved for $100,000 from DCED tied to its $1.5 million expansion of its Pittsburgh headquarters, at 2100 Wharton St., where the company is leasing an additional 4,200 square feet. The funding consists of a $50,000 opportunity grant and $50,000 in customized job training funds.
Invivodata would receive the money in return for retaining 66 existing employees and creating 40 new jobs over the next three years.

UMB BioPark Signs Gliknik as First Tenant for Its BioInnovation Center
Gliknik, a Baltimore biotech company, has agreed to be the first tenant in the BioInnovation Center, located within Building Two of the University of Maryland, Baltimore BioPark.  
Gliknik, a developer of drugs for autoimmune diseases and cancer, is based on research by Scott Strome, professor and chairman of the department of otorhinolarynogology within the University of Maryland School of Medicine.
The BioInnovation Center consists of 8,500 square feet of space, including 10 wet labs, five office suites, a shared conference room, kitchenette, and equipment room. The center provides affordable, pre-built wet lab and office space through short-term leases. Gliknik will reside in two labs once its buildout is complete, a project expected by March.
Gliknik was represented in its lease deal by the real estate firm Grubb & Ellis.
UMB BioPark consists of 360,000 square feet in two multitenant buildings developed by Wexford Science + Technology, and a 638 space parking garage. UMB credits the project with generating 200 jobs and $128 million in capital investment.

Real Estate Company Agrees to Market Science City, Other Projects of Three Developers
Real estate marketer EJ E-House China has agreed to serve as sales agent for properties of three Chinese developers, China Vanke, Neo-China Holdings, and Central China Real Estate, also known as Jianye, under a “strategic cooperation” agreement announced last week.
EJ will be the exclusive sales agent for 16 Vanke projects in 10 cities. The gross floor area available for sale in 2008 is expected to be approximately 1 million square meters (10.8 million square feet) with total sales value of approx 12 billion yuan renminbi ($1.65 billion). In addition, EJ will be the exclusive sales agent for at least half of Vanke’s new projects to be launched in eastern China in 2008. EJ will also provide real estate market research and consulting services for Vanke related to the developer’s projects in the region.
Vanke’s portfolio of residential projects include one within the 9,259-acre Science City of Guangzhou.
The strategic cooperation with Jianye will initially cover four projects in Henan province with a combined area of approximately 850,000 square meters (9.1 million square feet).

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.