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Eli Lilly, Millipore, Cambridge Major Laboratories, StemCyte, Wake Forest University Health Science, Carter Winstanley, Yale University, Sanford Health

Lilly Completes $1B Biotech Complex in Indianapolis
Eli Lilly last week said that it had completion construction of the final phase of a $1 billion biotechnology research and development complex in Indianapolis.
Lilly officials and Indianapolis Mayor Gregory Ballard last week dedicated the final phase of the Bioproduct Research and Development Laboratory, known as K362, which is the pharma’s headquarters for biotechnology R&D.
The 475,000-square-foot, four-story laboratory houses around 500 scientists and support staff working on molecular and cell biology, analytical science, and engineering [see related article, this issue].
The final phase marks the completion of three facilities that make up the biotechnology complex. The first phase of construction, completed in October 2006, was a 250,000-square-foot bioproduct pilot-manufacturing plant, while the second phase, which also opened in the fall of 2006, was a 10,000-square-foot facility that houses support staff. These two facilities house nearly 300 scientists and support staff.
“This completed biotechnology complex gives us the ability to capitalize on the synergies of being colocated with our drug discovery in Indianapolis,” said Steven Paul, executive vice president of science and technology and president of Lilly Research Laboratories, in a statement. “This facility basically allows us to quadruple the throughput of our biotechnology pipeline.”
Ballard said that Lilly’s decision to keep nearly 800 high-paying jobs in Indianapolis “is tremendous for our city and underscores the growing life sciences sector here in Indiana.”

Millipore Plans $3.4M Expansion in Missouri
The St. Louis Business Journal reported last week that Millipore plans to spend $3.4 million to add new space and that it plans to hire 60 more employees for its drug discovery unit in the St. Louis metropolitan area.
The expansion will fill more space at one of the company's three buildings in Missouri Research Park in St. Charles, the paper reported. These buildings served as the headquarters and main production facilities of Linco Research, a company that Serologicals purchased in May 2006 for $64.5 million. Serologicals paid an additional $10.3 million for the land and buildings Linco occupied at the time.
Millipore created a drug discovery unit from the Linco business after acquiring Serologicals in 2006.

Cambridge Major Labs To Break Ground on Germantown, Wisc., Manufacturing Site
Cambridge Major Laboratories said last week that it will break ground on a new manufacturing site in Germantown, Wisc., on June 5.
The new 120,000-square-foot facility will be dedicated to manufacturing multi-ton quantities of active pharmaceutical ingredients, Cambridge Major Labs said.
Completion is scheduled for August of 2009.
The facility will house six manufacturing suites with reactors up to 2,000 gallons. It will also house vessels for hydrogenation and cryogenic reactions. The facility has been designed to accommodate additional manufacturing suites up to 4,000 gallon scale, which will be built out as needed, the company said.
Cambridge Major opened a small-volume manufacturing site in Germantown in 2004, and this facility is approaching the maximum of its operating capacity, the company said.
The new facility will be focused on later stage clinical and commercial API’s. The company said that it has three API development sites in the US and Europe that “will feed large-scale manufacturing opportunities into the new site.”

StemCyte Opens New Facility in Covina, Calif.
Stem cell therapy developer StemCyte hosted an opening ceremony last week for a new 36,000-square-foot facility in Covina, Calif., the Pasadena Star-News reported.
The company relocated from a 12,000-square-foot facility in Arcadia, Calif., the paper reported.
The new building offers increased storage capacity for the company's supply of plasma-depleted umbilical cord blood stem cell products, which it collects and stores for use as therapeutic treatments.
The company chose the Covina location, at 1589 W. Industrial Park St., “because the building was outfitted with a specialized air filtration system left by the former tenants, which manufactured blood bags,” the paper reported.

Wake Forest to Convert Brownfields Site to Biotech Space
Wake Forest University Health Science disclosed last week in a legal notice that it plans to convert 1.27 acres in downtown Winston-Salem, NC, from a brownfields property into a biotechnology research and office site, the Winston-Salem Journal reported.
The request was filed with the N.C. Department of Environment and Natural Resources.
Bonnie Davis, a spokesman for Wake Forest University Baptist Medical Center, told the paper that the proposed project would reuse buildings vacated as part of a reorganization by R.J. Reynolds Tobacco Co.

Winstanley to Construct Garage, Retail Space in Science Park
The New Haven Register reported last week that real estate developer Carter Winstanley, an investor in the New Haven, Conn., Science Park project, plans to lease another parcel at the park for a garage and retail space.
Winstanley’s development company will also oversee construction of a 29,300-square-foot chiller plant for Yale University behind the garage, the paper reported.
Winstanley recently bought 25 Science Park, a renovated building that was set up as an incubator for biotech and other research-oriented businesses [See BioRegion News 11-05-07]. 
The developer now plans to construct a five-level, 1,200-space parking garage for tenants of 25 Science Park with retail space on the first floor that would be marketed to businesses that could serve the neighborhood, as well as firms at Science Park, according to the New Haven Register.
A site plan will go before the City Plan Commission this week and Winstanley said he hopes to complete construction within 14 months, the paper reported.

Sanford Health to Break Ground on 185-Acre Project
Sanford Health, a medical center based in Sioux Falls, SD, will break ground June 2 on a 185-acre biomedical research facility on the south side of the city, the Sioux Falls Argus Leader reported last week.
Sanford officials said that the planned facility will encompass 2 million square feet and could eventually support more than 6,000 jobs.
Construction will begin in summer 2009 with completion in 2011.
The park is one of several biomedical research projects that Sanford Health has planned for Sioux Falls. Sanford Children's Hospital is scheduled to open in spring 2009, and the center also plans to develop a new heart and vascular building on the north end of its campus.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.