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Colorado Gov. Bill Ritter, Colorado BioScience Association, Celsense, Pittsburgh Life Sciences Greenhouse, Turner Construction, Northwestern University, NAIOP, Leo A. Daly

New Law Lets Colorado Set Aside $2.5M for SBIR Matching Grants
Colorado Governor Bill Ritter signed into law May 23 a bill that will provide $2.5 million in matching grants for Colorado bioscience companies that receive funding under the federal Small Business Innovative Research program. The bill also adds biofuels to the categories of projects eligible for proof-of-concept matching funds.
House Bill 1060 is an extension of last year's HB 1360, which provided $2 million in bioscience research grants to Colorado universities and research institutions. Under HB 1060, $2 million is earmarked to match the federal grants available to small businesses at a rate of 50 cents for every federal dollar, up to a maximum of $50,000 per business. The additional $500,000 is earmarked for the development of biofuel technology.
The legislation was sponsored by Colorado Rep. Jim Riesberg (D-Weld) and state Sen. Brandon Shaffer (D-Longmont), with support from the Colorado BioScience Association, whose more than 340 member organizations represent both bioscience companies and companies providing key services to the bioscience industry and research institutions in Colorado.

Celsense Wins $150K Investment from Pittsburgh Life Sciences Greenhouse
The public-private Pittsburgh Life Sciences Greenhouse announced May 24 that it has invested $150,000 in Celsense to help further the commercialization of its flagship product Cell Sense, an MRI tracer agent that labels cells in culture.
“The Cell Sense technology shows a great deal of promise in the facilitation of therapies for many diseases,” said John Manzetti, PLSG’s president and CEO, in a press release announcing the funding. “The investment that the PLSG is committing today will help accelerate and improve the work of many researchers so that they in turn, can more effectively work to support doctors’ efforts to improve the lives of patients.”
The Pittsburgh Life Sciences Greenhouse fosters the growth of biosciences companies in Southwestern Pennsylvania. Celsense was founded in 2005 to commercialize imaging platforms licensed exclusively from Carnegie Mellon University.

Turner Selected to Build $59M Silverman Hall at Northwestern University
Turner Construction has been awarded a $59 million contract to serve as general contractor for the Northwestern University Richard and Barbara Silverman Hall for Molecular Therapeutics and Diagnostics in Evanston, Ill.
Upon completion in June 2009, the $100 million, 147,000-square-foot Silverman Hall will feature a biological imaging center and other core facilities, including therapeutics and diagnostics, proteomics and genomics, and bioinformatics.

A rendering of the Richard and Barbara Silverman Hall for Molecular Therapeutics and Diagnostics at Northwestern University in Evanston, Ill. The $100 million, 147,000-square-foot facility is set to be completed in June 2009.
SOURCE: Northwestern University
Silverman Hall will house 16 research groups in chemistry, biology, and engineering for 245 faculty, staff, and research assistants. The building will also house the Chemistry of Life Processes Institute, and feature a variety of meeting rooms and gathering spaces to encourage interaction and collaboration.
Silverman Hall has been designed as a “green” building and will seek approval from the United States Green Building Council for a Leadership in Energy and Environmental Design Silver Certification.
Richard Silverman recently donated to the university an undisclosed portion of the royalties he receives from sales of the drug Lyrica, which he developed while doing research at Northwestern. The gift will help fund the construction of Silverman Hall.
Zimmer Gunsul Fransca Partnership has designed the new building. Silverman Hall will be connected via pedestrian bridges with two other university buildings: the Pancoe-ENH Life Sciences Pavilion and Shirley W. Ryan Hall, extending the reach of the above-ground walkways that link Northwestern’s science facilities.

NAIOP Honors Leo A Daly for TIGR Facility
The Washington, DC, office of architectural firm Leo A. Daly has won "Best Biotech Office" honors from the Maryland/DC chapter of the National Association of Industrial and Office Properties for the design of the Institute for Genomic Research, a four-story, 122,000-square-foot laboratory and office facility located on a genetic research campus in Rockville, Md.
The award was part of the NAIOP chapter’s Fifth Annual Awards of Excellence program held at the Willard Intercontinental Hotel on May 3.

Using colors intended to evoke intended to evoke the dyes used to identify various amino acids, the glass curtainwall of The Institute for Genomic Research (TIGR) in Rockville, Md., is among design features that have garnered "Best Biotech Office" honors for the facility’s architect, the Washington, D.C. office of Leo A. Daly.
SOURCE: Leo A. Daly

Leo A. Daly provided full architectural, master planning, and interior design services for TIGR, an addition to the existing J. Craig Venter Institute research campus. Daly’s design was intended to evoke the Prairie style of American architecture, popularized by Louis H. Sullivan and his contemporary Frank Lloyd Wright in the early 20th century.

The design was intended to create functional spaces that facilitate communication among researchers and staff and provide a high-tech setting reflecting the nature of the advanced genomic research conducted within. A highlight of the building is its glass curtainwall interspersed with alternating bands of tinted and clear glass in hues of pink, blue, yellow, and green, intended to evoke the dyes used to identify nucleic acids in genome sequencing.
Since occupying the completed building, the teams of researchers at TIGR have been responsible for sequencing and analyzing more than 50 microbial genomes and some of the most important model organisms. A new sequence of one complete human genome will be published in early summer 2007.
Leo A. Daly employs more than 1,200 architects, planners, engineers and interior designers in 20 offices worldwide.

RIEDC, RIMES Forge New Alliance to Promote Growth in Manufacturing
The Rhode Island Economic Development Corporation and the Rhode Island Manufacturing Extension Service announced a new alliance aimed at strengthening the state's manufacturing sector.
As part of the collaboration, RIMES will relocate in June from North Kingstown, R.I., to the corporation's Valley Street offices in Providence, within the American Locomotive Works building. In addition, members of the RIMES team will work closely with members of RIEDC's business development team to more actively promote each organization’s services, intending to promote and support manufacturing activity statewide.
Created in 1996, RIMES assists small and medium-size manufacturers in Rhode Island, with the goals of helping them solve business problems and raising their level of competitiveness and profitability. RIMES offers programs aimed at helping manufacturers run more efficient factories, facility planning counseling, strategic growth services, organizational development, and supply chain services.
Since its inception, RIMES has provided support to more than 600 Rhode Island manufacturers, including biotechs.
Manufacturers who worked with RIMES between 2000 and 2005 reported increased or retained sales totaling $67.8 million, $24 million spent on new investment, 1,202 jobs created or retained, improved quality in services, up to a 50 percent increase in space utilization, and productivity improvements of 10 percent to 30 percent, the organization said.

Guava Technologies Expands with Opening of European Office
Guava Technologies of Hayward, Calif., announced May 23 that it has established a European office just outside of London in Stamford, UK. The office will focus on growing Guava’s business in Europe, Africa, and the Middle East, and on building deeper relationships with customers in those parts of the world.
The Stamford office — at 3 Southview Business Center, Tinwell Road — will initially include sales and marketing, administrative, shipping and receiving, and other operational functions. The office is overseen by Paul Wheeler, Guava’s director of EMEA operations.
Founded in 1998, Guava is a biotechnology and medical device company that develops benchtop cell analysis systems.

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Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.