Skip to main content
Premium Trial:

Request an Annual Quote

TGen, Collaborators Awarded NIH Grant to Validate RNA Biomarkers of Brain Injury

NEW YORK (GenomeWeb) – The National Institutes of Health has awarded researchers at the Translational Genomics Research Institute $2.8 million in grant funding over the next three years to continue an effort to identify extracellular RNAs as biomarkers for the severity of hemorrhagic stroke and risk of subsequent injury.

The grant was issued under the NIH's Extracellular RNA Communication program, which was established in 2012 to support research around the release, transport, uptake, and regulatory role of extracellular RNA molecules such as microRNAs and other non-coding RNAs.

Investigators from Phoenix Children's Hospital and the Barrow Neurological Institute are collaborating with TGen on the project.

"Because exRNAs are released from all tissues in the body, including the brain, they make an ideal candidate as a biomarker to help doctors in the evaluation and treatment of patients with brain injury," TGen's Kendall Van Keuren-Jensen, a co-principal investigator on the grant, said in a statement. "Ultimately, this research could lead to the development of new treatments and improved outcomes in hemorrhagic stroke patients."

The research, which focuses on two types of hemorrhagic events: aneurysmal subarachnoid hemorrhage (ASH) and pediatric intraventricular hemorrhage (IVH), extends work begun in 2013 in which cerebrospinal fluid and plasma from ASH and IVH patients underwent RNA sequencing in order to discover potential markers that can predict the onset of vasospasm and the severity of delayed neurological defects.

With the new funding, the investigators aim to run an additional round of biomarker discovery in additional patient samples, then validate the top candidates.

"In the best-case scenario, these markers can be coupled with an improved clinical management of the disease, too," Matt Huentelman, a TGen researcher and co-principal investigator on the grant, added in the statement.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.