At the 2012 meeting of the American Society for Clinical Oncology in Chicago this week, the Dana-Farber Cancer Institute's Levi Garraway chaired a session on research into different mechanisms of resistance to targeted anti-cancer therapeutics. In his research on melanoma, Garraway says he's seen that there are a number of mechanisms tumor can use to reactivate the pathways that sustain them. For example, in the MAP kinase pathway, RAF inhibitors, MEK inhibitors, and ERK inhibitors could all be used to block melanoma cell proliferation.

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In Science this week: swapping yeast genes with human orthologs to study conservation of function, and more.

Hong Kong is using DNA phenotyping to shame litterers.

A study appearing in Cell suggests some metastatic castration-resistant prostate cancer patients could benefit from PARP inhibitor therapy.

NIH's Francis Collins writes that scientific advances are poised to help populations all over the world, but more scientists are needed to keep the momentum.