At the 2012 meeting of the American Society for Clinical Oncology in Chicago this week, the Dana-Farber Cancer Institute's Levi Garraway chaired a session on research into different mechanisms of resistance to targeted anti-cancer therapeutics. In his research on melanoma, Garraway says he's seen that there are a number of mechanisms tumor can use to reactivate the pathways that sustain them. For example, in the MAP kinase pathway, RAF inhibitors, MEK inhibitors, and ERK inhibitors could all be used to block melanoma cell proliferation.

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In Genome Research this week: methylation patterns in multiple myeloma, recent Y chromosome bottleneck, and more.

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