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Yale University, Ingeneus


Yale University has received US Patent Number 6,403,319, “Analysis of sequence tags with hairpin primers,” for rolling circle amplification creator Paul Lizardi’s invention of a method for analyzing nucleic acid samples. In the method, nucleic acid fragments are amplified using a hairpin primer, then coupled to detector probes, and these groups are detected. The method is designed to facilitate quick analysis of a complex nucleic acid sample.


Ingeneus of Bridgetown, Barbados, has received US Patent Number 6,403,313, “Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators.” The invention described is a nucleic acid hybridization assay that can detect specific hybridization between double-stranded target DNA and single-stranded probes, eliminating the need to denature target DNA. The assay can also detect duplexes between single strands. The purpose of the assay is to identify accessible regions of folded nucleotide sequences as well as the number of mismatched pairs in a hybridization complex, and for genome mapping.