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Xtrana, Icoria, AGY Therapeutics, Robert Nadon


Xtrana of Broomfield, Colo., has received US Patent No. 6,872,527, "Nucleic acid archiving." The patent covers a process for tightly binding nucleic acids to solid phase and corresponding processes for the utilization of the method. These processes include nucleic acid - double- or single-stranded DNA and RNA -captures from high volume and low concentration specimens, buffer changes, washes, and volume reductions, and enables the interface of solid-phase bound nucleic acids with enzyme, hybridization or amplification strategies. The tightly-bound nucleic acid may be used, for example, in repeated analyses to confirm results or test additional genes in both research and commercial applications. Further, a method is described for virus extraction, purification, and solid-phase amplification from large-volume plasma specimens.

Icoria of Research Triangle, NC, has received US Patent No. 6,873,914, "Methods and systems for analyzing complex biological systems." The patent covers an invention that provides methods and systems for organizing complex and disparate data. More specifically, the patented invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the patented invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, according to Icoria, such as determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound sites of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

AGY Therapeutics of South San Francisco, Calif. has received US Patent No. 6,876,930, "Automated pathway recognition system." The patent covers techniques and systems for facilitating identification of candidate genes from a plurality of DNA sequences. The patented invention uses computer-implemented methods and systems to efficiently extract and process information on gene pathways and gene relationships and combine this information with results of other analyses in order to facilitate the rapid analysis of gene expression data. The invention provides a method that integrates the enormous amount of public literature regarding gene function with data from gene expression profiling experiments. It also provides a method for analyzing a group of genes identified through analysis of gene expression profiling experiments, wherein the groups of genes have been grouped together by a commonality in their gene expression patterns. Another embodiment of the patented invention provides a method for using both supervised and unsupervised clustering algorithms to automatically group genes by their expression pattern. The gene expression data analyzed may be from microarray experiments.

Robert Nadon et al. of St. Catharine's, Ontario, have received US Patent No. 6,876,929, "Process for removing systematic error and outlier data and for estimating random error in chemical and biological assays." The patent covers a method for improving the reliability and/or accuracy of physical measurements obtained from array hybridization studies performed on an array having a large number of genomic samples uses a small number of replicates insufficient for making precise and valid statistical inferences. The method described recommends overcoming this problem by estimating an error in measurement of a sample by averaging errors obtained when measuring the large number of samples or a subset of the large number of samples. The estimated sample error is utilized as a standard for accepting or rejecting the measurement of the respective sample. The samples may be independent or dependent in that correlated across two or more conditions.


The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.