Wisconsin Alumni Research Foundation of Madison, Wis., has received US Patent No. 7,067,322, "Fusion protein arrays on metal substrates for surface plasmon resonance imaging." The patent claims methods for making surface plasmon resonance-capable arrays where molecules, such as proteins or nucleic acids, are adhered to a metal substrate. The metal substrates are modified by depositing an O-modified alkanethiol monolayer to the substrate and then contacting the O-modified monolayer with a heterobifunctional linking compound, according to the patent.
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