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Versalinx Kits HRP and AP, GeneLinker Gold, Phoretix Array Database v2.0, BRB-ArrayTools Version 2.0

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Prolinx of Bothell, Wash., has released two new products for protein detection, Versalinx rapid protein-enzyme conjugation Kits HRP and AP. Versalinx chemical affinity technology utilizes the specific interaction between molecules containing P(D)BA (phenyl(di)boronic acid) and SHA (salicylhydroxamic acid) to link or attach nucleic acids, proteins, and other macromolecules for use in analytical and preparative assays. The new detection products use the Versalinx complex to attach an enzyme molecule (horseradish peroxidase or alkaline phosphatase) to any protein probe. Prolinx recently introduced its Versalinx chip kits, based on the same chemistry.

 

Molecular Mining Corporation of Raleigh, N.C., has released version 2.0 of its gene expression analysis software GeneLinker Gold. In addition to improved speed and data handling, new features include 3-dimensional principal component analysis plots, summary statistics and profile matching. They complement the existing self organizing maps (SOMs) and Jarvis-Patrick clustering (also known as mutual nearest neighbors).

Nonlinear Dynamics of Newcastle upon Tyne, UK, has released Phoretix Array Database v2.0., to be used with the recently upgraded Phoretix Array v3.0. The new database version introduces a data mining wizard allowing improved statistical capabilities, including principal component analysis, multidimensional scaling and correspondence analysis. It also has a reworked interface.

 

BRB-ArrayTools Version 2.0 will be available from the National Cancer Institute next week at http://linus. nci.nih.gov/BRB-ArrayTools.html. It will include a global test of clustering in PCA space. The software is free of charge to academic and non-profit institutions; companies can license it.

 

Agilent Technologies is holding seminars free-of charge around the US on its new microarray-related technologies. Upcoming seminar dates are: 1/29/02, Research Triangle Park, NC; 1/30/02, Bethesda, Md.; 1/31/02, Piscataway, NJ; 2/5/02, San Diego, Calif. ; 2/6/02, San Francisco; 2/7/02, Houston. Participants can register online at www.agilent.com/chem.

The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.