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The US Department of Health and Human Services, Epoch Biosciences, Surface Logix, Battelle Memorial Institute


The US Department of Health and Human Services has received US Patent No. 6,699,710, “Tumor tissue micro-arrays for rapid molecular profiling,” for an invention by Olli Kallioniemi, Juha Kononen, and Stephen Leighton of the National Human Genome Research Institute. The patent covers an array technology for profiling human tumors that consists of “hundreds of cylindrical tissue biopsies” 0.6 mm in diameter from different tumor regions arrayed in a paraffin blocks. These tissue arrays are designed for gene copy number and expression profiling of tumors.

Epoch Biosciences has been awarded US Patent No. 6,699,975, “Fluorescent quenching detection reagents and methods.” The patent covers oligonucleotide-fluorophore-quencher conjugates, in which the fluoro-phore moiety has emission wavelengths of between 300 nm and 800 nm, and where the quencher has a 4-(phenyldiazenyl) phenylamine structure. The conjugates are designed to improve signal-to-noise ratios in hybridization and other assays.

Surface Logix has received US Patent No. 6,699,665, “Multiple array system for integrating bioarrays.” The patent covers a microarray system that integrates arrays that include biological, chemical, and biochemical elements. These arrays are synthesized with soft litho-graphy and elastomeric membranes that act to cover portions of the substrate for biomolecule depositions. Holes in the membranes are used to stratify, isolate, or shield biomolecules in making the array.

Battelle Memorial Institute has received US Patent No. 6,699,384, “Compact electrochemical sensor system and method for field testing for metals in saliva or other fluids.” The patent covers microanalytical systems that involve microfluidics and electrochemical detection. These portable platforms include microfabricated piezoelectrically actuated pumps, a microelectrochemical cell, and other components that can be changed out or repaired, in a “plug and play” manner. One version of this invention includes all of the modules on the surface of the platform, and allows the microelectrochemical flow cell to be plugged into the microfluidic platform directly. Another version includes different modules stacked in multiple layers. The patent describes use of the system for detection of lead in river water and saliva samples.


The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.