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University of Texas, Texas A&M University, Perlegen Sciences, Affymetrix

The University of Texas of Austin and Texas A&M University of College Springs have received US Patent No. 7,341,552, “Gene sets for glioma classification.” The patent claims a number of gene markers whose expression is altered in various gliomas. In particular, by examining the expression of these markers, one can accurately classify a glioma as glioblastoma multiforme, anaplastic astrocytoma, anaplastic oligodendroglioma, or oligodendroglioma, the patent states. The diagnosis may be performed on nucleic acids, for example, by using a DNA microarray, according to the patent.

Perlegen Sciences of Mountain View, Calif., has received US Patent No. 7,341,865, “Liquid delivery devices and methods.” The patent claims methods and devices for using high-density arrays of diverse chemical entities. In preferred embodiments, small volumes of multiple liquids are delivered to multiple reaction sites on a single substrate where the liquids are constrained to localized reaction sites. The substrate does not need to be cut apart prior to being used for analysis. Accordingly, the area of the substrate on which analysis may be performed is maximized, the patent states.

Affymetrix has received US Patent No. 7,341,835, “Methods of analysis of alternative splicing in mouse.” The patent claims nucleic acid sequences that are complementary to a wide variety of mouse genes. The sequences are described in such a way as to make them available for a variety of analyses. In one embodiment, the nucleic acid sequences provided are present as an array of probes that may be used to measure gene expression of different mature RNA isoforms from at least 5,000 alternatively spliced mouse genes.