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University of Michigan, Sony, Hitachi, Affymetrix, PerkinElmer

The University of Michigan of Ann Arbor, Mich., has received European Patent No. 1774020, "Phage microarray profiling of the humoral response to disease." The patent claims compositions and methods for using a phage microarray to profile prostate, breast, or lung cancer. The patent also claims markers useful for the diagnosis, characterization, and treatment of disease. The method calls on the use of a phage library where phage clones made of cDNA obtained in an mRNA sample from various diseases are stored. The library is then enriched by binding it to a control IgG to remove non-disease specific clones from the library. Subsequently, the library is bound to a disease-specific IgG to enrich it for disease-specific phage clones. The enriched library is then exposed to serum from disease patients and non-disease control patients to generate an immunoglobulin bound phage library. Phage clones that react with the serum from the disease patients are then identified.

Sony of Tokyo has received European Patent No. 1775589, "DNA chip manufacturing method, manufacturing system, hybridization detection method, detection system, substrate treatment device, and substrate treatment method." The patent claims DNA chips for efficient hybridization and accurate detection of hybridization. The patent uses a discoid substrate with detecting elements that have a reaction area for hybridization and opposing electrodes. The electrodes are arranged to apply an electric field to a medium in the reaction area. The opposing electrodes apply an electric field that immobilizes the nucleic acid for detection onto the detection surface, brings about hybridization between the nucleic acid for detection and the target nucleic acid, and removes excess substances.

Hitachi of Kanagawa, Japan, has received US Patent No. 7,208,277, "Method for correcting inter-pin spotting amount error for a microarray." The patent claims a method of obtaining more accurate data from microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using pins. Upon microarray production, samples are immobilized on a microarray support using all pins as controls for correcting the inter-pin spotting amount errors, the patent states. After the microarray experiments, luminescent intensities of the samples used as control spots for correcting the inter-pin spotting amount errors are measured and used to obtain correction parameters for the inter-pin spotting amount errors of respective pins. These parameters are used to correct luminescent intensities of other samples.

Affymetrix has received US Patent No. 7,208,295, "Multiplex oligonucleotide addition and target amplification." The patent describes methods for appending oligonucleotides directly to nucleic acid templates, particularly to defined sites internal to single-stranded templates. The oligonucleotides may be designed to provide one or more sites for priming the subsequent amplification of adjacent template regions. The methods may be readily multiplexed, permitting oligonucleotides to be appended, in a single reaction, to a plurality of templates. In multiplex embodiments, the templates may then be concurrently amplified using primers common to all templates.

PerkinElmer of Waltham, Mass., has received US Patent No. 7,209,836, "Method and system for automatically creating crosstalk-corrected data of a microarray." The patent claims a method and system for automatically creating crosstalk-corrected data of a microarray using calibration dye spots. The method calls for the use of a microarray scanner, such as a confocal laser microarray scanner, that generates dye images, each of which contains at least one of the calibration dye spots for each of the output channels of the scanner. For each of the calibration dye spots, an output of each of the output channels is then measured to obtain output measurements. Finally, a set of correction factors is computed from the output measurements to correct the data subsequently gathered from the microarray scanner, the patent's abstract states.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.