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University of Illinois, Azign Bioscience of Copenhagen, US Department of Health and Human Services, Virginia Tech Intellectual Properties, Stratagene, Picoliter


The board of trustees of the University of Illinois received US Patent No. 6,706,474, “Nucleic acid enzyme biosensors for ions.” A method of detecting the presence of an ion includes contacting a nucleic acid enzyme with a sample suspected of containing the ion, where the enzyme contains a ribonucleotide and is dependent on the ion to produce a product from a substrate, and measuring an amount of the product produced.

Azign Bioscience of Copenhagen, Denmark, received US Patent No. 6,706,476, “Process for amplifying and labeling single stranded cDNA by 5’ ligated adaptor mediated amplification.”The patent covers adaptors and primers used for single-stranded cDNA amplification. The method comprises contacting RNA with an anchored cDNA synthesis primer and a specially designed adaptor that ligates to the 3’ end of single-stranded cDNA by T4 DNA ligase. The inventors describe this approach for the generation of probes starting from low amounts of RNA that may be used in microarray hybridization.

The US Department of Health and Human Services received US Patent No. 6,706,867, “DNA array sequence selection.” The patent covers methods for the construction of custom cDNA microarrays by selecting relevant clusters based on knowledge and expression patterns from public database information and the identification of the best representative cDNA clones within the selected cluster. The methods facilitate the construction of custom microarrays. In preferred embodiments, the present invention provides the the ImmunoChip.

Virginia Tech Intellectual Properties of Blacksburg, Va., received US Patent No. 6,706,479, “Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips.” The patent covers a method that detects binding of molecules without tagging molecules in the sample. The technology includes a sensor with a single stranded nucleic acid sequence and a photoluminescent material in respective layers. Methods for making tagging-free sensors to detect binding of antigens and related devices are included.

Stratagene received US Patent No. 6,706,879, “Fluorescent dye.” The patent covers a group of novel, water-soluble fluorescent cyanine dyes with distinct characteristics that permit their use in any assay or method suited to water-soluble fluorescent dyes, and especially for assays requiring distinguishable fluorescent markers.

Picoliter received US Patent No. 6,707,038, “Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface.” The patent covers a method for depositing analysis-enhancing fluid on a sample. The method uses focused radiation, typically acoustic radiation, to eject a droplet of the fluid.

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