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University of Chicago, Stephen Felder, Zyomyx, Takeo Tanaami, Albert Einstein College of Medicine


The University of Chicago has received U.S. Patent No. 6,458,584, “Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable.” Customized oligonucleotide microchips are used as biosensors for the detection and identification of nucleic acids specific for different genes, organisms, and/or individuals in the environment, in food, and in biological samples.

Stephen Felder of Tucson, Ariz., has received U.S. Patent No. 6,458,533, “High throughput assay system for monitoring ESTs.” This system provides a method for high throughput analysis of multiple samples. A combined system is provided which is useful for the detection of one or more targets in a sample. This combination comprises a surface for the introduction of a sample containing one or more targets and a biological or chemical array.

Zyomyx has received U.S. Patent No. 6,454,924, “Microfluidic devices and methods.” The patent claims a microfluidic device technology that allows the integration of high-performance protein biochips with mass spectrometry analyses.

Takeo Tanaami has received U.S. Patent No. 6,458,545, “Biochip.” The biochip enables the reduction of the cost of testing blood and consists of a collection block for retaining collected blood, a preprocessing block for deriving a target from the collected blood, and a substrate on which probes are deposited in arrays. The opening is closed airtight with a rubber plug.

Albert Einstein College of Medicine of Yeshiva University in New York City has received U.S. Patent No. 6,458,566, “Method of identification of differentially expressed MRNA.” “Differential expression using customized amplification libraries” (DECAL) permits global comparisons of bacterial gene expression under varied growth conditions. Amplified products derived from RNA samples can be hybridized to replicate colony blots or colony arrays, and the resulting hybridization patterns compared to determine the differentially expressed genes present in the original RNA samples.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.