The Regents of the University of California received US Patent No. 6,696,271, “Frozen tissue microarray technology for analysis of RNA, DNA, and proteins.” The patent covers tissue microarray technology that utilizes uniform fixation across the array panel by using frozen tissues embedded in tissue-embedding compounds as donor samples and arraying the specimens into a recipient block comprising an embedding compound. Tissue is not fixed prior to embedding, and sections from the array are evaluated without fixation or post-fixed according to the appropriate methodology used to analyze a specific gene at the DNA, RNA, and/or protein levels. Unlike paraffin tissue arrays, which can be problematic for immunohistochemistry and for RNA in situ hybridization analyses, the disclosed methods allow optimal evaluation by each technique.
Pandmics of Redwood City, Calif., received US Patent No. 6,696,256, “Method, array and kit for detecting activated transcription factors by hybridization array.” The patent covers a system for rapidly and efficiently identifying and quantifying multiple different activated transcription factors in a biological sample simultaneously. The system includes the step of mixing a library of transcription factor probes with a sample containing activated transcription factors. The transcription factor probes that have bound to the activated transcription factors may be isolated from the complexes formed between the probes and the activated transcription factors. The bound probes can be identified, for example, by using an array of hybridization probes.
Applied Gene Technologies of San Diego received US Patent No. 6,696,255, “Nucleic acid hairpin probes and uses thereof.” This patent includes oligonucleotide probes containing hairpin structures, or arrays of such oligonucleotide probes immobilized on a solid support, which are suitable for hybridization analyses are described as well as a system for nucleic acid hybridization analysis using the probes or array of immobilized probes.
Kimberly-Clark Worldwide of Neenah, NJ, received US Patent No. 6,696,254, “Detection and identification of enteric bacteria.” The invention provides probes, antibodies and methods for detecting a gene that is only found in Enterobacteriaceae, the deoxyguanosine triphosphate triphosphohydrolase gene. These probes and methods are designed for detecting whether test samples, including food and water samples, are infected with enteric bacteria.
3M Innovative Properties of St. Paul, Minn., received US Patent No. 6,696,157, “Diamond-like glass thin films.” The patent includes a diamond-like glass film containing at least about 30 atomic percent carbon, at least about 25 atomic percent silicon, and less than or equal to about 45 atomic percent oxygen on a hydrogen-free basis. The diamond-like glass film may be applied to various substrates.