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University of California, NuGen Technologies, Bureau of Animal and Plant Health Inspection and Quarantine, Electronics and Telecommunications Research Institute

The University of California of Oakland has received US Patent No.7,402,286, “Capillary pins for high-efficiency microarray printing device.” The patent provides a microarray print head that includes glass or quartz-spotting capillaries in a support. A fixed spacing between the spotting capillaries is maintained that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.

NuGen Technologies of San Carlos, Calif., has received US Patent No. 7,402,386, “Global amplification using random priming by a composite primer.” The patent discloses methods, compositions, and kits for global amplification. The methods provide for amplification using a composite primer that is capable of binding to multiple sites within template polynucleotides, where a large multiplicity of template polynucleotide sequences is amplified. The methods are suitable for use with either DNA or RNA template and generate polynucleotide products that are suitable for a variety of uses including comparative genome hybridization, expression profiling, and multiple genotype determinations, for example, by multiplex analysis by microarray technologies.

The Bureau of Animal and Plant Health Inspection and Quarantine of Taipei, Taiwan, has received US Patent No. 7,402,411, “Species-specific probes for identification of target virus and identification method using said probes.” The patent provides a method for identifying a target virus in an infected subject by: a) designing a pair of degenerate primers corresponding to highly conserved regions of the target virus; b) designing a pair of species-specific primers according to highly variable sequences within the conserved regions of the target virus; c) preparing the species-specific probes according to the larger sequence variations within the conserved regions of the target virus, which are amplified with the species-specific primers as obtained; d) preparing a test sample by amplifying total nucleic acid of the infected subject with the degenerate primers as obtained; contacting the test sample with the species-specific probes as obtained; and e) detecting a hybridization between the species-specific probe and the test sample, where the hybridization indicates the target virus is identified in the infected subject.

Electronics and Telecommunications Research Institute of Daejeaon, Korea, has received US Patent No. 7,403,236, “Programmable mask and method of fabricating biomolecule array using the same.” The patent describes a programmable mask that can be used in a photolithographic process for fabricating a biomolecule array and a method of fabricating a biomolecule array using the same mask.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.