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University of California, LG Electronics, Packard Instruments, Andcare


The University of California has received US Patent Number 6,395,562, “Diagnostic microarray apparatus.” The patent covers an invention by Bruce Hammock, Horacio Kito, and Angel Macquiera that involves an assay system with a solid support and at least one capture agent. The reagents and capture binding agents are immobilized on the support by a computer-controlled printing system that involves an ink-jet printer. The surface has areas that are digitally readable by a laser, which stores information on binding between analytes and capture agents. The assay system can additionally be used to perform chemical analyses including matrix assistedl laser desorption ionization mass spectrometry analyses.


LG Electronics of Seoul, South Korea, has received US Patent Number 6,391,625, “Biochip and method for patterning and measuring biomaterial of the same.” The patent covers DNA chips and protein chips that have a reflective layer as well as an active layer, and describes manufacture and detection methods. In the manufacture method, the chip is rotated and irradiated with a pulse laser beam to activate the layer, then the biomaterial pattern is fixed on activated regions. The biomaterial is detected through a reaction with a labeled dye material, the chip is rotated, and laser beams are directed at the chip. Using the light that bounces back from the chip as a result of the reaction, the material on the surface is measured.


Packard Instruments, now PerkinElmer, has received US Patent Number 6,395,554, “Microarray loading/unloading system.” The patent describes a slide loading apparatus that includes a slide storage cassette, and a slide feeder with grippers that grip the end of the slide and transport it to a sample holder.


Andcare of Durham, North Carolina, has received US Patent Number 6,391,558, “Electrochemical detection of nucleic acid sequences.” This patent describes an electrochemical detection system that utilizes biological probes to detect nucleic acid segements. These probes are complementary to the target segments, and hybridize with these segments. To detect hybridization, an electric potential is applied to the surface. A resulting current indicates the presence of a bound molecule.

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.